Endocrine Abstracts

Background: Cortisol is an essential stress hormone and deficient patients suffering a systemic inflammatory response (SIR) will rapidly die if not replaced. However, controversy remains on the definition for a normal adrenal response in critically ill patients. We investigated cortisol status in patients undergoing coronary artery bypass surgery (CABG), surgery frequently associated with a SIR, varying in severity from sub-clinical, to life-threatening....

Objectives: To determine the prevalence of several polymorphisms associated with increased cardiovascular risk in a group of adolescents with T1DM. To study the possible association of some polymorphisms with the occurrence of microvascular complications.Methods: Patients were randomly selected from our outpatient clinic. The following polymorphisms were studied:: ACE Ins/Del, Apo B R3500Q, Apo E2, 3, 4, MTHFR C677T and A1298C, PAI 4G/5G, ITGB3 PL(A1)/(A...

Background: Adiponectin is an important adipokine to which have been attributed anti-diabetic and anti-atherogenic properties. Excess of abdominal fat deposition is undoubtedly assumed as a cardiometabolic risk factor. It has been hypothesized that peripheral deposition of fat could exert a protective effect in cardiometabolic profile.Aims: To evaluate the influence of anthropometric parameters on adiponectin levels in both obese and normal-weight premen...

Introduction: Quality of life (QoL) is a subject of increasing interest in the health context. Applied to a chronic condition like diabetes, this issue could give an overall perspective of the health outcome.Objective: To evaluate the coping mechanisms, the treatment issues and its contribution to QoL of diabetes patients.Patients and methods: We gathered a sample of 94 diabetic subjects, 50% males, 55.3% type 1, with a mean age of...

Langerhans cell histiocytosis (LCH) is a rare disease often involving the hypothalamo-pituitary axis. Extreme obesity is frequent, but effective treatment is not. Malabsorptive bariatric surgery techniques are effective for weight loss in hypothalamic dysfunction. Laparoscopic sleeve gastrectomy (LSG) has recently emerged as a restrictive bariatric procedure to be used before biliopancreatic diversion or gastric bypass, thus reducing surgery-associated morbidity in particularl...

The pocket protein family members, pRb, p107 and p130, are negative regulators of the cell cycle. But, while the role of pRB as a tumor suppressor has been extensively established, genetic inactivation of p107 or p130 is uncommon in tumors. Previous studies have shown that p130 cooperates with the CDK inhibitor p27Kip1 restricting proliferation of mouse intermediate lobe pituitary cells. Accordingly double knockout mice show higher incidence of pituitary tumors than single KO ...

Pituitary carcinomas are rare but represent a particular challenge to clinical practice. We report a case of pituitary carcinoma with metastatic disease in a separate non-contiguous foci within the central nervous system. A 64 year old man presented with a large non-functioning pituitary adenoma manifesting as headache, third pair of cranial nerves paralysis, panhypopituitarism and impaired visual acuity in 1996.The tumour was grossly removed through a right pterional cranioto...

Objective: To evaluate the associations between baseline leisure-time physical activity (LTPA) or changes in LTPA during follow-up on long-term weight changes, and to investigate the effects of physical activity in participants with baseline BMI<25 kg/m2 and baseline BMI≥25 kg/m2.Material and methods: Data of the prospective dynamic cohort (SUN cohort) were used. In total 12 117 participants, all of them university graduat...

Surgery followed by 131I ablative therapy (IAT) is the usual treatment for patients with differentiated thyroid carcinoma (DTC). Thyroglobulin levels obtained 9–12 months after IAT under TSH stimulation (Tg2) is a very reliable marker for the presence of thyroid tissue. The value of stimulated thyroglobulin previous to ablation (Tg1) is more controversial. The aim of this study was to examine the relationship between Tg1 and Tg2.Material ...

The simultaneous occurrence of MTC and PTC in the same thyroid can be observed as a mixed tumour folliculo-medullar (OMS 1988) or as a collision tumour separated by normal thyroid parenchyma, which has only been described in less than thirty patients. We report two cases.Case 1: A 72 years old woman who underwent total thyroidectomy for a multinodular goiter. Histology showed a 2.5 cm CPT in the left lobe and a 4.5 cm CMT in the right lobe. She received ...